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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Stem Cell Niche01:26

Stem Cell Niche

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Related Experiment Video

Updated: Nov 19, 2025

Isolation and Culture of Neural Crest Stem Cells from Human Hair Follicles
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Isolation and Culture of Neural Crest Stem Cells from Human Hair Follicles

Published on: April 6, 2013

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Neural crest-like stem cells for tissue regeneration.

Jennifer Soto1, Xili Ding2, Aijun Wang3,4,5

  • 1Department of Bioengineering, University of California Los Angeles, Los Angeles, California, USA.

Stem Cells Translational Medicine
|February 3, 2021
PubMed
Summary

Neural crest stem cells (NCSCs) and neural crest-like stem cells (NCLSCs) offer regenerative potential. This review covers NCLSC derivation methods and their therapeutic applications in tissue regeneration.

Keywords:
adult stem cellsdisease modelingneural crest stem cellsplacental stem cellsregenerative medicine

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Related Experiment Videos

Last Updated: Nov 19, 2025

Isolation and Culture of Neural Crest Stem Cells from Human Hair Follicles
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Feeder-free Derivation of Neural Crest Progenitor Cells from Human Pluripotent Stem Cells
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Isolation and Culture of Neural Crest Cells from Embryonic Murine Neural Tube
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Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Neural crest stem cells (NCSCs) are crucial for vertebrate development, forming diverse tissues.
  • NCSCs possess self-renewal and multipotency, contributing to craniofacial and peripheral nervous systems.
  • Neural crest-like stem cells (NCLSCs) can be generated from various sources, mimicking NCSC properties.

Purpose of the Study:

  • To review recent advancements in deriving neural crest-like stem cells (NCLSCs).
  • To explore the therapeutic potential of NCLSCs for tissue regeneration applications.

Main Methods:

  • Literature review of NCLSC derivation techniques.
  • Analysis of studies on NCLSC differentiation and therapeutic uses.

Main Results:

  • NCLSCs can be derived from pluripotent stem cells, placental, adult, and reprogrammed somatic cells.
  • NCLSCs exhibit differentiation capabilities comparable to NCSCs.
  • Emerging evidence supports NCLSC potential in regenerative medicine.

Conclusions:

  • NCLSC derivation methods are advancing rapidly.
  • NCLSCs hold significant promise for future tissue regeneration therapies.