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Related Experiment Video

Updated: Nov 19, 2025

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Long-Term Survival Following Sepsis.

Konrad Schmidt1, Jochen Gensichen, Carolin Fleischmann-Struzek

  • 1Center for Sepsis Control and Care (CSCC), Jena University Hospital; Institute of General Practice and Family Medicine, Jena University Hospital; Institute of General Practice, Charité-Universitätsmedizin Berlin; Institute of General Practice and Family Medicine, Munich University Hospital, Ludwig-Maximilians-Universität München; Center for Clinical Studies, Jena University Hospital; Clinic for Anaesthesiology and Intensive Care Medicine, Jena University Hospital; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Leipzig University; Institute of General Practice and Family Medicine, Ruhr-University Bochum; Institute of Medical Statistics, Computer Science and Data Sciences, Jena University Hospital.

Deutsches Arzteblatt International
|February 3, 2021
PubMed
Summary

Long-term survival for sepsis patients in Germany remains poor, with nearly 75% mortality four years post-diagnosis. This study highlights the need for improved acute and long-term care strategies for sepsis survivors.

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Area of Science:

  • Critical Care Medicine
  • Epidemiology
  • Health Services Research

Background:

  • Prospective registry studies on long-term sepsis survival in Germany were lacking.
  • The Jena Sepsis Registry (JSR) was established to address this gap.

Purpose of the Study:

  • To investigate the long-term survival of sepsis patients in Germany.
  • To identify predictors associated with reduced survival time.

Main Methods:

  • Prospective registry of 1975 sepsis patients from 2011-2015 at Jena University Hospital.
  • Long-term survival data (6-48 months) collected via general practitioner surveys.
  • Survival analysis using Kaplan-Meier estimators and Cox regression.

Main Results:

  • In-hospital mortality was 45%, with 74% overall mortality at 48 months.
  • Predictors of shorter survival included older age, nosocomial sepsis, diabetes, cerebrovascular disease, longer ICU stay, and renal replacement therapy.
  • High data availability (96.4%) from general practitioners ensured robust long-term survival tracking.

Conclusions:

  • The high long-term mortality underscores the need for enhanced acute sepsis management and comprehensive multi-sector long-term care.
  • Findings from this single-center study may have limitations in generalizability.