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Updated: Nov 18, 2025

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Identification and Characterization of Burkholderia pseudomallei from Localized Pyogenic Infections in Eastern India:

Prashanth Purushotham1, Srujana Mohanty1, Preetam Chappity2

  • 11Department of Microbiology, All India Institute of Medical Sciences, Bhubaneswar, India.

The American Journal of Tropical Medicine and Hygiene
|February 3, 2021
PubMed

Insights

Melioidosis, caused by Burkholderia pseudomallei, is an emerging infection in eastern India. This study found B. pseudomallei in localized pyogenic lesions, highlighting its clinical and microbiological profile in the region.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Melioidosis, a serious infection caused by Burkholderia pseudomallei, is increasingly recognized globally.
  • Limited data exists on the prevalence and characteristics of B. pseudomallei in localized pyogenic infections in eastern India.

Purpose of the Study:

  • To identify and determine the frequency of B. pseudomallei in localized pyogenic lesions in eastern India.
  • To describe the clinico-microbiological profile and antimicrobial susceptibility of B. pseudomallei isolates.

Main Methods:

  • Pus samples analyzed using standard microbiological techniques.
  • B. pseudomallei identification confirmed by Polymerase Chain Reaction (PCR).
  • Clinical, demographic, and antimicrobial susceptibility data were collected and analyzed.

Main Results:

  • Out of 245 samples, 137 bacterial isolates were obtained, with B. pseudomallei accounting for 24.8% (34 isolates).
  • The mean age of melioidosis patients was 39.1 years, with a male predominance (70.6%).
  • Head and neck abscesses were the most common presentation; all isolates were susceptible to ceftazidime, trimethoprim-sulfamethoxazole, imipenem, and doxycycline.

Conclusions:

  • Burkholderia pseudomallei is an emerging cause of localized pyogenic infections in eastern India.
  • The study highlights the importance of diagnostic vigilance for accurate identification and appropriate treatment of melioidosis.
  • Effective treatment options are available, with high clinical resolution rates observed.

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