Five new secondary metabolites from the fungus Phomopsis asparagi
Peng Zhou1, Shan Yan1, Yuanyuan Lu2
1Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China.
Abstract:
Five new compounds, including a pair of diphenylcyclopentenone enantiomers (±)-phomopsisin A (1), a sesquiterpenoid 15-hydroxylithocarin A (2), a new diketopiperazine alkaloid prenylcyclotryprostatin A (3) and 7-hydroxy-cis-L(-)-3,6-dibenzyl-2,5-dioxopiperazine (6), along with five known compounds were isolated from the fungus Phomopsis asparagi. Their structures were elucidated on the basis of spectroscopic analyses (1D and 2D NMR), theoretical electronic circular dichroism (ECD) calculation, modified Mosher's method, and X-ray crystallography. The racemates of (±)-phomopsisin A showed inhibition on α-glucosidase with IC50 of 30.07 ± 0.75 μM (positive control acarbose, 121 ± 2.7 μM).
More Related Videos
06:58Author Spotlight: Evaluation of Entomopathogenic Fungi in Wild Monochamus alternatus Populations for Biocontrol Applications in Forest Wood Borers
Published on: September 29, 2023
08:58An Effective Inoculation Method for Phytophthora capsici on Black Pepper Plants
Published on: September 16, 2022
Related Concept Videos
Fungal Phylum Ascomycota
Fungal Phylum Basidiomycota
Fungal Group Zygomycota
Bacterial Phylum Planctomycetes
Fungal Phylum Microsporidia
