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Eyes on coronavirus

Yan-Ping Li1, Ya Ma2, Ningli Wang2

  • 1Laboratory for Stem Cell & Retinal Regeneration, The Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.

Stem Cell Research
|February 3, 2021
PubMed

Insights

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may impact eye health. This study explores the role of ACE2 and CD147 receptors in human ocular cells, investigating potential coronavirus effects on eye tissues and diseases.

Area of Science:

  • Ophthalmology
  • Virology
  • Molecular Biology

Background:

  • Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a global pandemic.
  • Severe cases affect multiple systems, but ocular complications are not widely reported.
  • SARS-CoV-2 utilizes specific receptors for cell entry.

Purpose of the Study:

  • To investigate the presence and role of SARS-CoV-2 receptors in human ocular cells.
  • To understand the potential mechanisms of coronavirus involvement in ocular tissues and diseases.

Main Methods:

  • Analysis of ACE2 and CD147 (BSG) receptor expression in human ocular cells.
  • Literature review on coronavirus interactions with ocular tissues.

Main Results:

  • ACE2 and CD147 receptors are present in human ocular cells.
  • These receptors may facilitate SARS-CoV-2 entry into ocular tissues.
  • Potential implications for ocular manifestations of COVID-19.

Conclusions:

  • The presence of ACE2 and CD147 suggests human ocular cells are potential targets for SARS-CoV-2.
  • Further research is needed to elucidate the specific roles of these receptors in COVID-19-related eye conditions.
Keywords:
ACE2BSGCD147COVID-19CoronavirusEyeRASSARS-CoV-2

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