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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Mesenchymal Stem Cells for Mitigating Radiotherapy Side Effects.

Kai-Xuan Wang1, Wen-Wen Cui1, Xu Yang1

  • 1School of Medical Technology, Xuzhou Key Laboratory of Laboratory Diagnostics, Xuzhou Medical University, Xuzhou City 221004, China.

Cells
|February 4, 2021
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cells (MSCs) show promise in reducing radiation therapy side effects. This review explores MSC applications for mitigating radiotherapy-induced damage to healthy tissues.

Keywords:
mesenchymal stem cellsradiation-induced injuryradiotherapy

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Area of Science:

  • Oncology
  • Regenerative Medicine
  • Cell Biology

Background:

  • Radiotherapy, a cancer treatment, causes significant side effects by damaging healthy cells and tissues.
  • Radiation-induced injuries can be severe and irreversible, affecting organs like the skin, intestine, brain, lung, liver, and heart.
  • Effective strategies to mitigate these adverse effects are urgently needed.

Purpose of the Study:

  • To review current research on mesenchymal stem cells (MSCs) for mitigating radiotherapy side effects.
  • To discuss the therapeutic potential and future perspectives of MSCs in managing radiation injury.

Main Methods:

  • Literature review of studies investigating MSCs in the context of radiation therapy.
  • Analysis of MSC properties, including differentiation, immunomodulation, and paracrine secretion, relevant to mitigating radiation damage.

Main Results:

  • Mesenchymal stem cells (MSCs) are highlighted for their accessibility and therapeutic potential.
  • MSC-based therapies are being explored to counteract the damaging effects of radiation on various organs.
  • The review synthesizes current findings on MSCs' role in managing radiotherapy complications.

Conclusions:

  • Mesenchymal stem cells (MSCs) offer a promising avenue for reducing radiotherapy-induced side effects.
  • Further research and clinical application of MSCs could significantly improve patient outcomes after radiation therapy.
  • MSC immunomodulatory and paracrine functions are key to their radioprotective capabilities.