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Updated: Nov 18, 2025

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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
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Integrated Stroke System Model Expands Availability of Endovascular Therapy While Maintaining Quality Outcomes
Victor Lopez-Rivera1, Sergio Salazar-Marioni1, Rania Abdelkhaleq1
1Department of Neurology (V.L.-R., S.S.-M., R.A., S.I.S., A.L.C., Y.J.A., G.S., T.-C.W., L.D.M., S.A.S.), UTHealth McGovern Medical School, Houston, TX.
Stroke
|February 4, 2021
Summary
Implementing an integrated stroke system (ISS) expanded endovascular stroke therapy (EVT) access, significantly reducing treatment times for acute ischemic stroke patients. This model maintained quality standards across hospitals, even those with lower procedure volumes.
Area of Science:
- Neurology
- Vascular Surgery
- Health Systems Management
Background:
- Optimal care delivery for endovascular stroke therapy (EVT) remains undefined.
- An integrated stroke system (ISS) was developed to enhance EVT accessibility regionally.
- The system aimed to maintain high hospital and physician quality standards.
Purpose of the Study:
- To evaluate the impact of an integrated stroke system (ISS) on EVT availability and treatment times.
- To assess the quality metrics associated with EVT in a decentralized system.
- To validate the ISS model using external regional data.
Main Methods:
- Retrospective analysis of 513 patients with large vessel occlusion acute ischemic stroke treated with EVT (Jan 2014-Feb 2019).
- Implementation of ISS in Oct 2017, expanding EVT-Performing Hospitals (EPHs) to four.
- Comparison of pre-ISS and post-ISS cohorts, focusing on onset-to-arrival time and quality outcomes.
Main Results:
- ISS implementation reduced time from stroke onset to EPH arrival by 40 minutes and onset to groin puncture by 29 minutes.
- Interhospital transfer rates decreased post-ISS (46% vs. 37%).
- Quality metrics (hemorrhage, TICI 2b/3, 90-day mRS) were comparable across EPHs, irrespective of volume.
Conclusions:
- Expanding EVT availability through an ISS significantly decreases treatment times for acute ischemic stroke.
- The ISS model effectively supports quality care delivery in lower-volume hospitals.
- This integrated approach provides a viable framework for regional stroke care optimization.
Keywords:
acute ischemic strokeendovascular techniqueshealth care deliveryhealth occupations manpowerintegrated delivery systems
