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Quantifying lumbar vertebral perfusion by a Tofts model on DCE-MRI using segmental versus aortic arterial input

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Choosing the right arterial input function (AIF) significantly impacts vertebral perfusion quantification with dynamic contrast-enhanced MRI (DCE-MRI). Patient-specific segmental arterial AIFs provide more accurate results than population-based or patient-specific aortic AIFs.

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Area of Science:

  • Medical Imaging
  • Biophysics
  • Pharmacokinetics

Background:

  • Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is crucial for assessing tissue perfusion.
  • Accurate quantification of perfusion parameters relies heavily on the arterial input function (AIF).
  • Vertebral perfusion assessment using DCE-MRI requires careful consideration of AIF selection.

Purpose of the Study:

  • To investigate how different arterial input function (AIF) selections influence the quantification of vertebral perfusion using axial DCE-MRI.
  • To compare the effects of population-based aortic AIF, patient-specific aortic AIF, and patient-specific segmental arterial AIF on pharmacokinetic parameters.

Main Methods:

  • Axial DCE-MRI was performed on lumbar vertebrae of healthy volunteers using a 1.5-T scanner.
  • Pharmacokinetic parameters (Ktrans, ve, vp) were calculated using a Tofts model with various AIFs (AIF_PA, AIF_A, AIF_SA).
  • Simulations and nonparametric statistical analyses (Wilcoxon signed rank test, Kruskal-Wallis test) were employed.

Main Results:

  • Simulations showed Ktrans and ve increased with decreased AIF peak, while vp increased with increased AIF delay.
  • In vivo, Ktrans and ve were significantly lower with patient-specific aortic AIF (AIF_A) compared to patient-specific segmental arterial AIF (AIF_SA).
  • Perfusion parameters were significantly greater when using AIF_SA compared to AIF_A.

Conclusions:

  • Patient-specific segmental arterial AIF (AIF_SA) provides more accurate vertebral perfusion quantification in DCE-MRI compared to aortic AIFs.
  • AIF selection critically affects the reliability of pharmacokinetic parameter estimation in vertebral DCE-MRI studies.
  • This highlights the importance of selecting an appropriate AIF for precise DCE-MRI-based perfusion analysis.