Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

10.5K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.5K
Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

7.6K
Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
7.6K
Peptide Bonds02:43

Peptide Bonds

80.2K
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
80.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sixty-five years of physiology: Australia's continuing contributions.

The Journal of physiology·2026
Same author

Synthesis of Macrocyclic Peptides via Photochemical Radical Thiol-yne Reaction.

Journal of the American Chemical Society·2026
Same author

Development and Biological Characterization of Fluorescent Dynorphins for the Visualization of Kappa Opioid Receptors.

Journal of medicinal chemistry·2026
Same author

A minimally invasive, scalable and reproducible neonatal rat model of severe focal brain injury.

Brain communications·2026
Same author

Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes.

Nature communications·2026
Same author

Photocaged Oxytocin and Vasopressin Probes to Decipher Neuropeptide Signalling With High Spatiotemporal Resolution.

Angewandte Chemie (International ed. in English)·2026

Related Experiment Video

Updated: Nov 18, 2025

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

12.1K

Trends in peptide drug discovery.

Markus Muttenthaler1,2, Glenn F King3, David J Adams4

  • 1Institute for Molecular Bioscience, The University of Queensland, Brisbane, QC, Australia. markus.muttenthaler@univie.ac.at.

Nature Reviews. Drug Discovery
|February 4, 2021
PubMed
Summary

Over 80 peptide drugs, including insulin, have been developed for various diseases. This perspective reviews peptide drug discovery trends and emerging strategies for future potential.

More Related Videos

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

9.6K
Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

5.3K

Related Experiment Videos

Last Updated: Nov 18, 2025

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

12.1K
A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

9.6K
Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

5.3K

Area of Science:

  • Pharmacology and Drug Discovery
  • Medicinal Chemistry
  • Biotechnology

Background:

  • Insulin's introduction nearly a century ago marked the beginning of peptide therapeutics.
  • Over 80 peptide drugs are now available for treating diverse conditions like diabetes, cancer, and HIV.
  • Peptide drugs offer significant therapeutic potential across numerous medical fields.

Purpose of the Study:

  • To summarize key trends in peptide drug discovery and development.
  • To highlight lessons from historical approaches and emerging strategies.
  • To discuss the pharmaceutical landscape and challenges for peptide drugs.

Main Methods:

  • Review of historical peptide drug discovery efforts (hormones, medicinal chemistry, natural products).
  • Analysis of advancements in molecular biology and peptide chemistry.
  • Exploration of emerging strategies like integrated venomics and peptide-display libraries.

Main Results:

  • Peptide drug development has evolved significantly from early hormone-based therapies.
  • Medicinal chemistry, rational design, and molecular biology have driven progress.
  • Emerging techniques offer new avenues for discovering novel peptide therapeutics.

Conclusions:

  • Peptide drugs have a proven track record and continue to expand their therapeutic reach.
  • Integrating historical lessons with novel strategies like venomics is crucial for future success.
  • Addressing challenges in development will unlock the full potential of peptide therapeutics.