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Mapping Dysfunctional Protein-Protein Interactions in Disease
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Mapping Dysfunctional Protein-Protein Interactions in Disease

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Roles of peptidyl-prolyl isomerase Pin1 in disease pathogenesis

Jingyi Li1,2, Chunfen Mo3, Yifan Guo2

  • 1The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan, China.

Theranostics
|February 4, 2021
PubMed

Insights

Pin1, a peptidyl-prolyl cis-trans isomerase, regulates key cell functions. Its dysregulation is linked to various diseases, making it a crucial factor in pathogenesis.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Pin1 is a peptidyl-prolyl cis-trans isomerase (PPIase) crucial for cellular functions.
  • It modulates cell cycle, motility, and apoptosis by catalyzing proline isomerization.
  • Pin1's dysregulation is implicated in numerous disease states.

Purpose of the Study:

  • To review the current understanding of Pin1's role in disease pathogenesis.
  • To highlight the significance of Pin1 in the development and progression of various diseases.

Main Methods:

  • Literature review of studies on Pin1 function and disease association.
  • Synthesis of current knowledge on Pin1's involvement in cellular processes and pathology.

Main Results:

  • Pin1's enzymatic activity is vital for normal cellular functions.
  • Aberrant Pin1 activity contributes to the pathogenesis of diverse diseases.
  • Pin1 is a potential therapeutic target for disease intervention.

Conclusions:

  • Pin1 plays a critical role in maintaining cellular homeostasis.
  • Understanding Pin1's function is key to deciphering disease mechanisms.
  • Targeting Pin1 may offer novel therapeutic strategies for various conditions.
Keywords:
Pin1neurodegenerative diseasespathogenesis of diseasespeptidyl-prolyl cis-trans isomerasesviral infection

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