Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.8K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.8K
The Ras Gene02:38

The Ras Gene

6.7K
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
6.7K
The Nucleolus02:55

The Nucleolus

9.8K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
9.8K
Abnormal Proliferation02:23

Abnormal Proliferation

4.9K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.9K
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

5.8K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.8K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.4K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Authentication of <i>Puerariae</i> <i>Lobatae Radix</i> and Its Adulterant <i>Puerariae Lobatae Caulis</i> via Digital ID Technology.

Foods (Basel, Switzerland)·2026
Same author

Cortical structure alterations in toddlers with different severities of congenital heart disease: a cross-sectional study.

European journal of pediatrics·2026
Same author

Evaluation of the interference of 49 commonly used clinical drugs on 60 biochemical tests.

Practical laboratory medicine·2026
Same author

Microplastics distinctly regulate cadmium accumulation and lipid homeostasis in maize: Mechanistic insights from membrane remodeling to gene expression.

Journal of hazardous materials·2026
Same author

VFLING: Vertical Federated Learning for Multi-Omics Data Integration with Graphs.

Interdisciplinary sciences, computational life sciences·2026
Same author

Phase-Resolved Defect Transport Mechanisms Governing Asynchronous Ordering in a Eutectic High-Entropy Alloy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Related Experiment Video

Updated: Nov 18, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.5K

Circular RNAs in Human Cancer.

Xiong Wang1, Huijun Li1, Yanjun Lu1

  • 1Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.

Frontiers in Oncology
|February 4, 2021
PubMed
Summary

Circular RNAs (circRNAs) are stable RNA molecules involved in various biological processes and cancer. This review explores their diverse functions in cancer, including miRNA sponging and protein interactions.

Keywords:
circRNAmiRNApeptidetranscriptiontranslation

More Related Videos

Use of Alu Element Containing Minigenes to Analyze Circular RNAs
13:10

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

7.6K
In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

1.8K

Related Experiment Videos

Last Updated: Nov 18, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.5K
Use of Alu Element Containing Minigenes to Analyze Circular RNAs
13:10

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

7.6K
In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

1.8K

Area of Science:

  • Molecular Biology
  • Genomics
  • Cancer Research

Background:

  • Circular RNAs (circRNAs) are covalently closed RNA molecules formed by back-splicing.
  • They are stable, conserved, and exhibit tissue-specific expression patterns.
  • circRNAs play critical roles in both normal physiology and cancer biology.

Purpose of the Study:

  • To review the current understanding of circRNA functions in human cancers.
  • To highlight circRNAs' roles as miRNA sponges, in protein interactions, and as templates for protein translation.
  • To summarize available databases for circRNA annotation and functional prediction.

Main Methods:

  • Literature review of circRNA research in cancer.
  • Analysis of deep sequencing and bioinformatics data.
  • Survey of databases for circRNA annotation and functional prediction.

Main Results:

  • circRNAs exhibit diverse functions including miRNA/protein sponging, scaffolding, and translation.
  • These functions contribute to the pathogenesis of various human cancers.
  • Numerous circRNAs are implicated in regulating transcription, splicing, translation, and protein degradation.

Conclusions:

  • circRNAs are key regulators in cancer development and progression.
  • Understanding circRNA functions is crucial for cancer research and therapeutic strategies.
  • circRNA databases aid in annotation and functional exploration for cancer studies.