Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

114
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
114
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

123
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
123
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

121
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
121

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neutrophil Extracellular Traps Promote Platelet-Driven Contraction of Inflammatory Blood Clots via Local Generation of Endogenous Thrombin and Softening of the Fibrin Network.

Cells·2025
Same author

Arterial human blood flow can be stopped by cables of VWF and platelets without coagulation.

Blood advances·2025
Same author

Shapes and Dimensions of Blood Clots Affect the Rate and Extent of Platelet-Driven Clot Contraction and Will Determine the Outcomes of Thrombosis.

bioRxiv : the preprint server for biology·2025
Same author

Red blood cell aggregation within a blood clot causes platelet-independent clot shrinkage.

Blood advances·2025
Same author

Exploring the thrombus niche: lessons learned and potential therapeutic opportunities.

Blood·2025
Same author

Ubiquitous clot contraction blockers hit ubiquitin and more.

Blood advances·2025
Same journal

Resolving the dilution paradox to improve the interpretation of extracellular vesicle biomarker studies.

Research and practice in thrombosis and haemostasis·2026
Same journal

Heparin to prevent recurrent placenta-mediated pregnancy complications in women with antiphospholipid syndrome: a systematic review.

Research and practice in thrombosis and haemostasis·2026
Same journal

Thromboembolic ischemic stroke induces neutrophil recruitment and matrix metalloproteinase-9 release to enhance ischemic brain injury.

Research and practice in thrombosis and haemostasis·2026
Same journal

Real-world investigation of platelet apoptosis for mechanistic insights into severe immune thrombocytopenia and bleeding.

Research and practice in thrombosis and haemostasis·2026
Same journal

Antiphospholipid antibody formation during immune checkpoint inhibition in patients with cancer: a prospective cohort study.

Research and practice in thrombosis and haemostasis·2026
Same journal

Venous thromboembolic and bleeding risk in population with obesity hospitalized for an acute medical illness receiving enoxaparin for thromboprophylaxis.

Research and practice in thrombosis and haemostasis·2026
See all related articles

Related Experiment Video

Updated: Nov 18, 2025

Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli
13:10

Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli

Published on: September 25, 2016

10.1K

Visualizing thrombosis to improve thrombus resolution.

John W Weisel1, Rustem I Litvinov1

  • 1Department of Cell and Developmental Biology University of Pennsylvania Perelman School of Medicine Philadelphia PA USA.

Research and Practice in Thrombosis and Haemostasis
|February 4, 2021
PubMed
Summary
This summary is machine-generated.

Understanding thrombus structure is key to treating thrombosis. New imaging and thrombectomy methods reveal how fibrin, platelets, and cells form varied thrombus morphologies impacting disease outcomes.

Keywords:
deep vein thrombosisischemic strokemyocardial infarctionpulmonary embolismthrombectomythrombolysisthrombosis

More Related Videos

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

17.6K
An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
07:50

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

Published on: June 4, 2021

3.0K

Related Experiment Videos

Last Updated: Nov 18, 2025

Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli
13:10

Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli

Published on: September 25, 2016

10.1K
A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

17.6K
An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
07:50

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

Published on: June 4, 2021

3.0K

Area of Science:

  • Cardiovascular Research
  • Hematology
  • Medical Imaging

Background:

  • Thrombosis severity depends on thrombus size and location.
  • Studying thrombus structure and composition is challenging.
  • Recent advances enable detailed thrombus analysis.

Purpose of the Study:

  • To review recent research on thrombus morphology.
  • To correlate morphologic characteristics with clinical and pathogenic factors.
  • To highlight the relevance for thrombosis management.

Main Methods:

  • Intravital imaging techniques.
  • Mechanical thrombectomy for thrombus extraction.
  • Microscopic analysis of thrombus structure and composition.

Main Results:

  • Thrombi contain diverse fibrin structures, platelet aggregates, leukocytes, and erythrocytes.
  • Platelet contraction leads to polyhedral cell shapes (polyhedrocytes).
  • Component volume fractions vary with clinical and pathogenic features.

Conclusions:

  • Thrombus morphology is a critical determinant of thrombosis outcomes.
  • Quantitative and qualitative analysis of thrombus structure aids understanding.
  • Morphologic insights are relevant for thrombosis pathogenesis, prophylaxis, diagnosis, and treatment.