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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
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Congenital Cutaneous Candidiasis With Systemic Dissemination in a Preterm Infant.

Isabel Miras1, Eva Vierge2, Macarena García3

  • 1From the Department of Pediatrics and Neonatology, Hospital Universitario de Guadalajara, Guadalajara, Spain.

The Pediatric Infectious Disease Journal
|February 4, 2021
PubMed
Summary
This summary is machine-generated.

Congenital cutaneous candidiasis, a rare fungal infection, affects newborns, especially premature infants. Early recognition and treatment of skin lesions significantly reduce mortality in affected infants.

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Area of Science:

  • Neonatal dermatology
  • Infectious diseases
  • Mycology

Background:

  • Congenital cutaneous candidiasis is a rare invasive fungal infection presenting in neonates.
  • Extremely low birth weight infants are particularly susceptible.
  • The condition can lead to systemic dissemination if not managed promptly.

Observation:

  • The classic presentation involves an erythematous rash with papules, plaques, pustules, and vesicles, followed by desquamation.
  • Systemic involvement is frequent in extremely low birth weight infants.
  • Initial assessment should include blood, urine, and cerebrospinal fluid analysis.

Findings:

  • Early recognition of skin lesions is crucial for timely intervention.
  • Prompt and sustained antifungal treatment is associated with reduced mortality rates.
  • This case highlights successful early management in a preterm infant.

Implications:

  • Emphasizes the importance of vigilant dermatological assessment in neonates.
  • Highlights the need for prompt initiation of antifungal therapy in suspected cases.
  • Suggests that early intervention can significantly improve outcomes for congenital cutaneous candidiasis.