Related Experiment Videos
Heritable pulmonary lobation anomaly in the rat
H Aoyama1, S Teramoto, Y Shirasu
1Mitsukaido Laboratories, Institute of Environmental Toxicology, Ibaraki, Japan.
Teratology
|February 1, 1988
Summary
A novel gene mutation in Wistar rats causes fused lung lobes, a condition inherited in an autosomal recessive pattern. This fused pulmonary lobes (fpl) gene also leads to semi-lethality and other developmental abnormalities.
Area of Science:
- Genetics
- Developmental Biology
- Animal Models
Background:
- Genetic mutations can lead to significant developmental abnormalities.
- Understanding gene function is crucial for studying congenital defects.
Purpose of the Study:
- To identify and characterize a novel gene mutation causing fused lung lobes in Wistar rats.
- To determine the inheritance pattern and potential pleiotropic effects of the mutation.
Main Methods:
- Genetic analysis of Wistar rats exhibiting fused lung lobes.
- Phenotypic characterization of homozygous mutants (fpl/fpl).
Main Results:
- A new autosomal recessive mutant gene, fused pulmonary lobes (fpl), was identified.
- fpl/fpl homozygotes displayed fused lung lobes, semi-lethality, and associated malformations (e.g., malocclusion, eyelid and digit anomalies).
Conclusions:
- The fpl gene is responsible for fused lung lobes in Wistar rats.
- The fpl gene exhibits pleiotropic effects, influencing multiple developmental pathways.