Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Solvent-triggered reconfiguration of optical physical unclonable functions.

Nature communications·2026
Same author

Extreme Nanoconfinement Dramatically Enhances Small Molecule Solubility in Nonpolar Polymers.

ACS nano·2026
Same author

Squeezing new information out of small systems.

The Journal of chemical physics·2026
Same author

The Effect of Nanoparticle Shape, Orientation, and Heterogeneity on the Optical Birefringence of Polymer Nanocomposites.

The journal of physical chemistry. C, Nanomaterials and interfaces·2026
Same author

pH-Tunable, Ligand-Free Selective Separation of Rare Earth Elements Using Silica Nanoparticles.

ACS applied materials & interfaces·2026
Same author

Suppression of Macroscopic Phase Separation in Polymer Blends Confined within the Interstitial Pores of Dense Nanoparticle Packings.

ACS nano·2026

Related Experiment Video

Updated: Nov 18, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.4K

pH-Mediated nanoparticle dynamics in hydrogel nanocomposites.

Katie A Rose1, Daeyeon Lee1, Russell J Composto2

  • 1Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA. daeyeon@seas.upenn.edu composto@seas.upenn.edu.

Soft Matter
|February 4, 2021
PubMed
Summary

Static silica particles affect quantum dot (QD) nanoparticle movement in hydrogels. pH-controlled interactions between PEG brushes and silica surfaces dictate QD nanoparticle mobility, impacting drug delivery and nanofiltration applications.

More Related Videos

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

10.1K
Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

23.0K

Related Experiment Videos

Last Updated: Nov 18, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.4K
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

10.1K
Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

23.0K

Area of Science:

  • Materials Science
  • Nanotechnology
  • Physical Chemistry

Background:

  • Hydrogel nanocomposites are engineered materials with tunable properties.
  • Controlling nanoparticle dynamics within hydrogels is crucial for applications like drug delivery.
  • Poly(ethylene glycol) (PEG) brushes are used to modify nanoparticle surfaces.

Purpose of the Study:

  • To investigate the effect of static silica particles on the dynamics of PEG-grafted quantum dot (QD) nanoparticles in hydrogel nanocomposites.
  • To understand the role of pH-mediated interactions between PEG brushes and silica surfaces on nanoparticle mobility.
  • To explore the potential for controlling nanoparticle transport in hydrogels.

Main Methods:

  • Single particle tracking (SPT) was employed to monitor PEG-QD dynamics.
  • Quartz crystal microbalance with dissipation (QCM-D) was used to quantify interactions between PEG brushes and silica particles.
  • Experiments were conducted at varying silica concentrations and pH levels.

Main Results:

  • At low silica concentration (Φ = 0.005), two PEG-QD populations (localized and mobile) were observed, unlike in neat hydrogel.
  • Increasing silica concentration altered the hydrogel network structure, complicating direct analysis of silica's effect.
  • pH-dependent adsorption of PEG-QDs onto silica was confirmed: strong adsorption at pH 5.8 (hydrogen bonding) and negligible adsorption at pH 9.2 (deprotonated silanol groups).
  • SPT results corroborated QCM-D findings, showing localized PEG-QDs at pH 5.8 and mobile PEG-QDs at pH 9.2.

Conclusions:

  • pH-mediated interactions between PEG brushes and silica surfaces significantly control PEG-QD nanoparticle dynamics in hydrogel nanocomposites.
  • This pH-dependent control offers a strategy for tuning nanoparticle transport.
  • Findings have implications for optimizing nanoparticle-based drug delivery systems and nanofiltration technologies.