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Updated: Nov 18, 2025

Mutagenesis and Functional Selection Protocols for Directed Evolution of Proteins in E. coli
Published on: March 16, 2011
Xuxu Zhong1, Meijun Duan2, Peng Cheng3
1National Key Laboratory of Fundamental Science on Synthetic Vision, Sichuan University, Chengdu, China.
This study introduces a novel ranking-based hierarchical random mutation in differential evolution (RHRMDE) algorithm. RHRMDE enhances performance by applying different mutation strategies to distinct population groups, improving both exploration and convergence.
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