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Related Experiment Video

Updated: Nov 18, 2025

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

Deiodinases and Cancer.

Annarita Nappi¹, Maria Angela De Stefano¹, Monica Dentice¹

¹Department of Clinical Medicine and Surgery, University of Naples "Federico II," Naples, Italy.

|February 4, 2021

Summary

Thyroid hormone (TH) levels are altered in many cancers. Deiodinase enzymes regulate TH action within cells, and their altered expression in tumors impacts cancer progression, potentially serving as diagnostic or therapeutic targets.

Keywords:

cancer deiodinase proliferation thyroid hormone action

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Area of Science:

Endocrinology
Oncology
Molecular Biology

Background:

Hormones, particularly thyroid hormone (TH), significantly influence cancer development.
Intratumoral TH concentration changes are common in human neoplasias.
Deiodinase enzymes control intracellular TH availability, acting as a key cell-autonomous mechanism.

Purpose of the Study:

To review recent findings on the interplay between deiodinases and cancer.
To elucidate the role of deiodinases in cancer progression.
To explore the potential of deiodinase expression as a diagnostic or therapeutic tool in oncology.

Main Methods:

Literature review of research on deiodinases and cancer.
Analysis of the regulatory networks (growth factors, oncogenes, miRNA) affecting deiodinase expression in cancer cells.
Discussion of the functional consequences of altered TH availability in tumors.

Main Results:

Deiodinase expression is dynamically regulated in cancer cells by complex molecular networks.
Altered deiodinase activity impacts intracellular TH levels, influencing cancer cell functions.
Specific deiodinase expression patterns are frequently observed in various tumors.

Conclusions:

Deiodinases play a critical role in cancer progression through modulation of intracellular thyroid hormone.
Deiodinase expression patterns may serve as valuable biomarkers for tumor staging.
Targeting deiodinases presents a potential therapeutic strategy for cancer treatment.