Related Experiment Video

Updated: Jun 18, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.2K

Paediatric ischaemic stroke is a valid diagnosis in the Swedish National Patient Register

Anna Walås1, Katarina Svensson1, Maria Gyris2

  • 1Department of Pediatrics, Division of Children's and Women's Health, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Acta Paediatrica (Oslo, Norway : 1992)
|February 4, 2021
PubMed

Insights

The Swedish National Patient Register accurately identifies paediatric ischaemic stroke cases, with a high positive predictive value (PPV). This confirms its reliability for epidemiological research on childhood stroke.

Area of Science:

  • Epidemiology
  • Neurology
  • Public Health

Background:

  • The Swedish National Patient Register is a valuable resource for epidemiological studies.
  • Accurate diagnostic data is crucial for reliable research on paediatric ischaemic stroke.

Purpose of the Study:

  • To validate the accuracy of paediatric ischaemic stroke diagnoses recorded in the Swedish National Patient Register.
  • To assess the register's suitability for future epidemiological research on childhood stroke.

Main Methods:

  • A cohort of 1606 individuals diagnosed with paediatric ischaemic stroke (ICD-10: I63, I64) between 1969-2016 was identified.
  • 292 cases were randomly selected for medical chart review to validate the register's diagnoses.
  • The positive predictive value (PPV) for paediatric ischaemic stroke was calculated.

Main Results:

  • Of 273 reviewed charts, 242 (89%) had a correct paediatric ischaemic stroke diagnosis.
  • The PPV for paediatric ischaemic stroke in the National Patient Register was 89% (95% CI: 0.85-0.92).
  • The Medical Birth Register showed a PPV of 97% for perinatal stroke diagnoses.

Conclusions:

  • The Swedish National Patient Register demonstrates high reliability for paediatric ischaemic stroke research.
  • The PPV supports the use of the register for epidemiological studies on childhood stroke.
  • Diagnostic accuracy improved over time, with increased confirmation by radiology.
Abstract

Keywords:
National Patient Registerischaemic strokepaediatricperinatalvalidation

More Related Videos

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats07:56

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

10.8K
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.3K

Related Concept Videos

Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...