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Maternal celiac disease and the risk for long-term infectious morbidity of the offspring

Naim Abu-Freha1, Tamar Wainstock2, Aerin Philip3

  • 1The Institute of Gastroenterology and Hepatology, The Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

American Journal of Reproductive Immunology (New York, N.Y. : 1989)
|February 4, 2021
PubMed

Insights

Children born to mothers with celiac disease face a higher risk of long-term infections. This study found increased rates of bacteremia and central nervous system infections in these offspring, highlighting maternal celiac disease as a significant risk factor.

Area of Science:

  • Immunology
  • Pediatrics
  • Public Health

Background:

  • Celiac disease, an autoimmune disorder, is linked to increased infection risk in patients.
  • Offspring of mothers with celiac disease exhibit elevated morbidity.
  • Understanding the long-term infectious disease burden in these children is crucial.

Purpose of the Study:

  • To evaluate the long-term infectious disease risk in children born to mothers with celiac disease.
  • To compare infectious morbidity between offspring of mothers with and without celiac disease.

Main Methods:

  • A population-based cohort study included deliveries from 1991-2014.
  • Offspring were grouped based on maternal celiac disease status.
  • Data on demographics, maternal, perinatal, and hospitalization records for infections were analyzed.

Main Results:

  • Offspring of mothers with celiac disease showed significantly higher cumulative infectious morbidity (log-rank p = .004).
  • Elevated rates of bacteremia (1.0% vs. 0.1%; p = .001) and central nervous system infections (1% vs. 0.2%; p = .028) were observed.
  • Maternal celiac disease was an independent risk factor for offspring's long-term infectious morbidity (aHR = 1.6, p = .005).

Conclusions:

  • Maternal celiac disease is an independent risk factor for increased long-term infectious morbidity in offspring.
  • This finding underscores the importance of monitoring children born to mothers with celiac disease for infections.
Abstract

Keywords:
Celiac diseaseinfectious morbiditylong-termoffspring

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