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Chronic Implantation of Multiple Flexible Polymer Electrode Arrays
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3D printed polymeric drug-eluting implants.

Athina Liaskoni1, Ricky D Wildman2, Clive J Roberts1

  • 1Advanced Materials and Healthcare Technologies, School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.

International Journal of Pharmaceutics
|February 4, 2021
PubMed
Summary
This summary is machine-generated.

3D printing creates personalized poly(ε-caprolactone) (PCL) implants for sustained drug delivery. This technology offers a promising alternative to conventional methods, improving patient compliance by reducing frequent dosing needs.

Keywords:
3D printingDrug deliveryImplantPersonalised medicinePolycaprolactoneSustained release

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Area of Science:

  • Materials Science
  • Pharmaceutical Technology
  • Biomedical Engineering

Background:

  • Conventional drug delivery systems often require frequent administration, leading to reduced patient compliance.
  • Poly(ε-caprolactone) (PCL) implants offer a potential solution for sustained drug release.
  • 3D printing technology allows for the fabrication of customized drug delivery devices.

Purpose of the Study:

  • To investigate the use of extrusion-based 3D printing for manufacturing sustained drug release PCL implants.
  • To evaluate the structural integrity, chemical properties, and drug release profiles of 3D printed PCL implants containing lidocaine.
  • To assess the effectiveness of PCL as a barrier for controlled drug elution.

Main Methods:

  • Hot-melt extrusion-based 3D printing of PCL implants with and without a core-shell structure.
  • Characterization using Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), X-Ray Diffraction (XRD), and Attenuated Total Reflectance Fourier Transform Infrared spectroscopy (ATR-FTIR).
  • Drug release studies utilizing a USP4 flow-through cell apparatus and analysis via the Korsmeyer-Peppas model.

Main Results:

  • 3D printed PCL implants maintained structural integrity and showed no significant chemical modifications.
  • All formulations exhibited sustained lidocaine release, with the PCL barrier proving effective in controlling elution.
  • The Korsmeyer-Peppas model accurately described the drug release kinetics for all tested implants.

Conclusions:

  • Extrusion-based 3D printing is a viable and robust technology for producing personalized, drug-eluting PCL implants.
  • This approach enhances drug delivery by providing sustained release and potentially improving patient compliance.
  • The study highlights the potential of 3D printing for advanced pharmaceutical manufacturing.