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Effect of androgens on phalloidin-induced liver toxicity in mice
Y Muraoka1, H Watanabe, M Kometani
1Shionogi Research Laboratories, Kanzakigawa Laboratory, Osaka, Japan.
Toxicology Letters
|March 1, 1988
Abstract:
A single i.p. dose of phalloidin, 0.75 or 1 mg/kg body weight, induced peliosis hepatis-like lesion (PHLL) at 3 h after injection to mice. Pretreatment with various doses of testosterone propionate for 7 days enhanced phalloidin-induced PHLL. Other anabolic steroids, methyltestosterone, methandriol. fluoxymesterone and oxymetholone had no effect.