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Functional Interaction among lncRNA HOTAIR and MicroRNAs in Cancer and Other Human Diseases

Monica Cantile1, Maurizio Di Bonito1, Maura Tracey De Bellis2

  • 1Pathology Unit, Istituto Nazionale Tumori-Irccs-Fondazione G.Pascale, 80131 Naples, Italy.

Cancers
|February 5, 2021
PubMed

Insights

Long non-coding RNAs (lncRNAs) regulate cancer by interacting with microRNAs (miRNAs). The lncRNA HOTAIR and its miRNA interactions are crucial in cancer progression, offering potential as biomarkers.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) are key regulators in cancer initiation, metastasis, and drug resistance.
  • lncRNAs modulate gene expression by interacting with microRNAs (miRNAs), acting as competing endogenous RNAs.
  • The lncRNA HOX transcript antisense RNA (HOTAIR) is implicated as a biomarker in various human cancers.

Purpose of the Study:

  • To review the relationship between the lncRNA HOTAIR and various miRNAs in human diseases.
  • To discuss the role of HOTAIR-miRNA interactions in cancer development and progression.

Main Methods:

  • Literature review
  • Analysis of functional interactions between lncRNAs and miRNAs
  • Focus on HOTAIR's role in cancer pathogenesis

Main Results:

  • lncRNAs, particularly HOTAIR, significantly influence cancer progression through miRNA sponging.
  • HOTAIR-miRNA interactions are critical for modulating cellular processes in cancer.
  • HOTAIR serves as a potential diagnostic, prognostic, and predictive biomarker.

Conclusions:

  • The interplay between HOTAIR and miRNAs is a critical mechanism in human cancer.
  • Understanding these interactions can lead to novel therapeutic strategies and biomarkers for cancer management.
Keywords:
cancer progressionlncRNA HOTAIRmiRNAs

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