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Ultrastructure of renal adenoma
1University Institute of Pathology, Aarhus Kommunehospital, Denmark.
Ultrastructural Pathology
|January 1, 1988
Summary
Renal adenomas are common kidney lesions. Ultrastructural analysis suggests they originate from abnormal gene expression, not specific nephron segments, with some similarities to renal cell carcinoma cells.
Area of Science:
- Nephrology
- Oncology
- Cell Biology
Background:
- Renal adenomas are frequent, small epithelial lesions in adult kidneys (15-22%).
- These lesions can co-occur with renal cell carcinoma.
- Their ultrastructure in human kidneys is not well-characterized.
Purpose of the Study:
- To investigate the ultrastructural characteristics of renal adenomas.
- To determine the cellular origin and potential relationship to renal cell carcinoma.
Main Methods:
- Study of 10 intrarenal adenomas from carcinoma-bearing kidneys.
- Rapid tissue fixation post-nephrectomy using glutaraldehyde perfusion.
- Ultrastructural analysis using electron microscopy.
Main Results:
- Confirmed tubular origin of renal adenomas.
- Demonstrated ultrastructural markers from various nephron segments within adenomas.
- Observed similarities to renal cell carcinoma cells, though less pronounced.
Conclusions:
- Renal adenomas do not appear to originate from a specific nephron segment.
- Their ultrastructure suggests abnormal gene expression in neoplastic cells.
- Findings indicate a potential link between adenomas and renal cell carcinoma development.