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Decreased serum bilirubin levels in children with lead poisoning

Mengsi Ye1, Tingting Zhang2, Zhibo Chen3

  • 1Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.

The Journal of International Medical Research
|February 5, 2021
PubMed

Insights

Lead poisoning in children significantly alters non-enzymatic antioxidants. Blood tests reveal lower albumin, bilirubin, urea, and creatinine levels, indicating oxidative stress in affected children.

Area of Science:

  • Environmental Health
  • Pediatric Toxicology
  • Biochemistry

Background:

  • Lead is a toxic heavy metal causing irreversible damage in children.
  • Oxidative stress is a key mechanism in lead toxicity.
  • Monitoring in vivo oxidative stress in lead-poisoned children is crucial.

Purpose of the Study:

  • To investigate blood serum levels of non-enzymatic antioxidants in children with lead poisoning.
  • To assess biochemical parameters including albumin, bilirubin, creatinine, and uric acid.

Main Methods:

  • A case-control study involving 355 children with lead poisoning and 355 matched controls.
  • Analysis of clinical characteristics and measurement of serum levels of total protein, globulin, albumin, bilirubin, aspartate aminotransferase (AST), urea, and creatinine.

Main Results:

  • Children with lead poisoning showed significantly lower levels of albumin, bilirubin, urea, and creatinine compared to controls.
  • Elevated levels of AST, total protein, and globulin were observed in lead-poisoned children.
  • Direct bilirubin, albumin, total protein, urea, creatinine, and AST levels were associated with lead poisoning, with bilirubin, albumin, and urea identified as independent indicators.

Conclusions:

  • Lead exposure interferes with the non-enzymatic antioxidant system in children.
  • Lead poisoning leads to a significant decrease in serum bilirubin levels.
Abstract

Keywords:
Childalbuminantioxidantbilirubinlead poisoningnon-enzymatic antioxidant

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