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Predicting visual acuity in Bietti crystalline dystrophy: evaluation of image parameters
Chu-Yen Huang1,2, Eugene Yu-Chuan Kang1,2, Lung-Kun Yeh1,2
1Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
BMC Ophthalmology
|February 5, 2021
Summary
Near-infrared reflectance (NIR) aids Bietti crystalline dystrophy (BCD) diagnosis. Ellipsoid zone (EZ) disruption on spectral domain-optic coherence tomography (SD-OCT) strongly predicts legal blindness in BCD patients.
Area of Science:
- Ophthalmology
- Medical Imaging
- Genetics
Background:
- Bietti crystalline dystrophy (BCD) is a rare inherited retinal disorder.
- Understanding imaging biomarkers is crucial for assessing visual acuity in BCD.
- Multimodal imaging offers insights into retinal structure and function.
Purpose of the Study:
- To analyze various imaging modalities in Bietti crystalline dystrophy (BCD) patients.
- To identify imaging factors associated with best corrected visual acuity (BCVA).
- To evaluate the predictive value of imaging findings for legal blindness.
Main Methods:
- Retrospective analysis of 40 eyes from 22 BCD patients.
- Categorization into groups based on BCVA (≤20/200 and >20/200).
- Evaluation of near-infrared reflectance (NIR), fundus autofluorescence (FAF), and spectral domain-optic coherence tomography (SD-OCT) findings.
Main Results:
- Near-infrared reflectance (NIR) effectively detects crystalline or sclerotic vessels in BCD.
- Patients with poorer visual acuity showed thinner choroids and ellipsoid zone (EZ) disruption.
- EZ disruption on SD-OCT is a significant predictor of legal blindness in BCD.
Conclusions:
- NIR is a valuable diagnostic tool for Bietti crystalline dystrophy (BCD).
- Ellipsoid zone (EZ) disruption, assessed by SD-OCT, strongly correlates with legal blindness in BCD.
- Multimodal imaging, particularly SD-OCT, aids in predicting visual outcomes.
Keywords:
Best corrected visual acuity (BCVA)Bietti crystalline dystrophy (BCD)Choroidal thicknessCrystallineEllipsoid zone disruptionFundus autofluorescence (FAF)Near-infrared reflectance (NIR)Sclerotic vesselsSpectral domain-optical coherence tomography (SD-OCT)
