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Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
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Chronic Thromboembolic Disease and Chronic Thromboembolic Pulmonary Hypertension

Irene M Lang1, Ioana A Campean1, Roela Sadushi-Kolici1

  • 1Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Währinger Gürtel 18-20, Vienna 1090, Austria.

Clinics in Chest Medicine
|February 5, 2021
PubMed

Insights

Chronic thromboembolic pulmonary hypertension (CTEPH) and related vascular disease (CTED) are rare but treatable conditions. Effective treatments include surgery, angioplasty, and approved medications like Riociguat and treprostinil.

Area of Science:

  • Cardiovascular Medicine
  • Pulmonary Medicine
  • Vascular Surgery

Background:

  • Chronic thromboembolic pulmonary hypertension (CTEPH) and chronic thromboembolic pulmonary vascular disease (CTED) represent uncommon but serious outcomes of venous thromboembolism.
  • These conditions are hypothesized to stem from a shared underlying pathophysiological process.

Purpose of the Study:

  • To summarize the current understanding and treatment landscape for CTEPH and CTED.
  • To highlight the efficacy of available therapeutic interventions.

Main Methods:

  • Review of existing literature on CTEPH and CTED pathophysiology and treatment.
  • Analysis of approved pharmacological and interventional therapies.

Main Results:

  • CTEPH and CTED are rare manifestations of venous thromboembolism, likely sharing a common pathophysiological basis.
  • Significant clinical improvement, approaching a cure, can be achieved through pulmonary endarterectomy, balloon pulmonary angioplasty, and medical therapies.

Conclusions:

  • Pulmonary endarterectomy and balloon pulmonary angioplasty are effective interventional treatments for CTEPH and CTED.
  • Pharmacological options including Riociguat and subcutaneous treprostinil offer approved medical management strategies for these conditions.

Keywords:
Acute pulmonary embolismChronic thromboembolic pulmonary hypertensionChronic thromboembolic pulmonary vascular diseaseVenous thromboembolism

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