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Lentivirus Production
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Update on Small Ruminant Lentiviruses.

Cindy Wolf1

  • 1College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, USA.

The Veterinary Clinics of North America. Food Animal Practice
|February 5, 2021
PubMed
Summary
This summary is machine-generated.

Small ruminant lentiviruses (SLRVs) cause lifelong infections in sheep and goats, leading to significant economic losses. Effective control requires understanding transmission and frequent, sensitive testing due to lack of vaccines or treatments.

Keywords:
Caprine arthritis encephalitis virusIndurative mastitisOvine progressive pneumonia virusSmall ruminant lentivirus

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Area of Science:

  • Veterinary Virology
  • Infectious Diseases
  • Animal Health

Background:

  • Small ruminant lentiviruses (SLRVs) are widespread, causing chronic infections in sheep, goats, and wild ruminants.
  • These viruses can cross species barriers, complicating disease management.
  • SLRVs induce lifelong infections targeting specific organs, leading to substantial economic losses in livestock production.

Purpose of the Study:

  • To summarize the impact and characteristics of small ruminant lentiviruses.
  • To highlight the challenges in controlling SLRV infections.
  • To emphasize the importance of diagnostic testing and transmission knowledge.

Main Methods:

  • Review of existing literature on SLRV epidemiology and pathogenesis.
  • Analysis of production impacts associated with SLRV infections.
  • Evaluation of current control strategies and their limitations.

Main Results:

  • SLRVs cause significant production losses, including reduced milk yield, increased neonatal mortality, and impaired growth.
  • Lifelong infections and organ-specific targeting are characteristic of SLRVs.
  • Current vaccines and treatments are ineffective against SLRVs.

Conclusions:

  • Effective control of SLRVs hinges on a thorough understanding of viral transmission dynamics.
  • Frequent, highly sensitive, and specific diagnostic testing is crucial for managing SLRV outbreaks.
  • Further research into novel treatment and vaccination strategies is warranted.