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Updated: Nov 18, 2025
Establishment and Genetic Manipulation of Murine Hepatocyte Organoids
Published on: February 12, 2022
Transcriptome-Guided Design of Physiological Multilineage Liver Organoids
Shijia Zhu1, Naoto Kubota1, Yujin Hoshida1
1Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
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Despite several technical challenges, human induced pluripotent stem cell (hiPSC)-derived organoids enable biologically and clinically relevant functional study of physiology and disease. In a recent Cell Systems article, Velazquez et al. report a novel strategy to identify regulators of multilineage organoid maturation by reverse-engineering from the global transcriptome of human tissues.
