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Migraines and keloids: a 15-year Taiwan claim database analysis
Ying-Yi Lu1,2,3, Hao Qin4, Chun-Ching Lu5
1Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Postgraduate Medical Journal
|February 5, 2021
Summary
Individuals with keloids have a significantly higher risk of developing migraines. This suggests keloids may be a risk factor for migraines, warranting medical examination for headaches in keloid patients.
Area of Science:
- Dermatology and Neurology
- Epidemiology
- Pathophysiology
Background:
- Keloids are fibroproliferative lesions causing scar growth, pruritus, and pain.
- Migraines are recurrent headaches aggravated by physical activity.
- Both conditions share similar pathways, including transforming growth factor-β1 and neurogenic inflammation.
Purpose of the Study:
- To investigate the subsequent development of migraines in adult patients diagnosed with keloids.
- To compare migraine incidence between keloid and non-keloid patient cohorts.
Main Methods:
- Retrieved data from Taiwan National Health Insurance Research Database.
- Included 9,864 patients with keloids and 39,456 matched controls without keloids.
- Utilized Cox proportional hazards regression to analyze migraine risk.
Main Results:
- 103 keloid patients and 323 non-keloid patients developed migraines.
- Keloid patients exhibited a 2.29-fold increased risk of migraine development.
- Females and patients under 50 were more susceptible to migraines within the keloid group.
Conclusions:
- Keloids may serve as a predisposing risk factor for migraine development in adults.
- Patients with keloids experiencing headaches should be evaluated for migraines.
- Further research into shared pathophysiological mechanisms is warranted.
