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The role of vaccines in combatting antimicrobial resistance

Francesca Micoli1, Fabio Bagnoli2, Rino Rappuoli3

  • 1GSK Vaccines Institute for Global Health, Siena, Italy.

Nature Reviews. Microbiology
|February 5, 2021
PubMed

Insights

Vaccines can significantly combat antimicrobial resistance (AMR) by preventing bacterial infections, thereby reducing antibiotic use. This review explores vaccine development against resistant pathogens and their impact on global health.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Vaccinology

Background:

  • Antimicrobial resistance (AMR) poses a significant global health threat, leading to increased morbidity and mortality.
  • Rising resistance to multiple drugs necessitates novel therapeutic and preventive strategies.

Purpose of the Study:

  • To review the evidence supporting the role of vaccines in combating AMR.
  • To discuss the development status of vaccines targeting resistant bacterial pathogens.
  • To explore obstacles and future impacts of vaccines on AMR.

Main Methods:

  • Literature review of existing research on vaccines and AMR.
  • Analysis of vaccine development pipelines for resistant bacterial pathogens.
  • Discussion of challenges and future prospects in vaccine-mediated AMR control.

Main Results:

  • Vaccines can reduce infectious disease incidence, consequently decreasing antibiotic consumption and AMR spread.
  • Vaccine development is ongoing for key resistant bacterial pathogens affecting diverse global populations.
  • Several obstacles impede vaccine progress, but next-generation vaccines hold promise for AMR impact.

Conclusions:

  • Vaccines represent a crucial prophylactic strategy to mitigate the global threat of AMR.
  • Continued investment and research in vaccine development are essential for controlling resistant bacterial infections.
  • Future vaccines are expected to play a pivotal role in reducing the burden of AMR worldwide.

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