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Related Concept Videos

Complement System01:27

Complement System

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The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
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Prognostic Value of Complement Properdin in Cancer.

Alessandro Mangogna1, Praveen M Varghese2,3, Chiara Agostinis1

  • 1Institute for Maternal and Child Health, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Burlo Garofolo, Trieste, Italy.

Frontiers in Immunology
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Summary
This summary is machine-generated.

Properdin, a key regulator of the complement system, shows potential as a cancer prognostic marker. Its levels correlate with immune cell infiltration and patient survival across multiple cancer types.

Keywords:
bioinformaticscancercomplementinnate immunityprognosisproperdin

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Area of Science:

  • Immunology
  • Oncology
  • Bioinformatics

Background:

  • The complement system, particularly the alternative pathway regulated by properdin, is activated by tumor cells.
  • Properdin's role in recognizing
  • altered-self
  • and its dysregulation in inflammation suggest a link to cancer development.

Purpose of the Study:

  • To investigate the correlation between properdin expression and cancer.
  • To evaluate properdin as a prognostic marker in lung adenocarcinoma (LUAD), liver hepatocellular carcinoma (LIHC), cervical squamous cell carcinoma (CESC), and pancreatic adenocarcinoma (PAAD).

Main Methods:

  • Bioinformatics analysis using Oncomine, UALCAN, and PROGgeneV2.
  • Analysis of tumor-infiltrating immune cells using TIMER.
  • Immunohistochemical analysis.

Main Results:

  • Properdin expression was lower in LUAD and LIHC tumors compared to normal tissues.
  • Higher properdin mRNA expression was associated with better overall survival in all four cancer types.
  • Properdin levels correlated with immune cell infiltration, with infiltrating immune cells being a likely source.

Conclusions:

  • Properdin shows promise as a prognostic biomarker in cancer.
  • Further research is warranted to explore properdin's role in the tumor microenvironment and cancer progression.