Related Experiment Video

Updated: Nov 18, 2025

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

1.9K

SGK1 in Human Cancer: Emerging Roles and Mechanisms

Yiwen Sang1, Piaoping Kong1, Shizhen Zhang2

  • 1Department of Laboratory Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Frontiers in Oncology
|February 5, 2021
PubMed

Insights

Serum and glucocorticoid-induced protein kinase 1 (SGK1) plays a key role in cancer development and progression. Its abnormal expression indicates cancer and can predict patient survival, making SGK1 a potential therapeutic target.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Serum and glucocorticoid-induced protein kinase 1 (SGK1) is an AGC subfamily kinase with similarities to AKT.
  • SGK1 dysregulation is linked to numerous human cancers.
  • SGK1 influences gene expression and signal transduction critical for cancer development.

Purpose of the Study:

  • To review SGK1's role as a diagnostic and prognostic biomarker in various cancers.
  • To elucidate SGK1's functions in tumorigenesis, proliferation, apoptosis, invasion, metastasis, autophagy, metabolism, and therapy resistance.
  • To summarize molecular mechanisms regulating SGK1.

Main Methods:

  • Systematic literature review.
  • Analysis of SGK1's involvement in cancer hallmarks.
  • Examination of SGK1 regulatory pathways.

Main Results:

  • Abnormal SGK1 expression is correlated with cancer progression and can serve as a diagnostic indicator.
  • SGK1 is implicated in key cancer processes including proliferation, apoptosis, invasion, and metastasis.
  • SGK1 influences tumor microenvironment, metabolism, and therapy resistance.
  • Understanding SGK1's regulatory mechanisms is crucial.

Conclusions:

  • SGK1 is a critical factor in tumorigenesis and cancer progression.
  • SGK1 functions as a valuable prognostic and diagnostic biomarker.
  • SGK1 represents a promising therapeutic target for diverse cancer types.
Keywords:
autophagymetabolismserum and glucocorticoid-induced protein kinase 1therapeutic resistancetumor microenvironment

More Related Videos

Analysis of SCAP N-glycosylation and Trafficking in Human Cells11:27

Analysis of SCAP N-glycosylation and Trafficking in Human Cells

Published on: November 8, 2016

9.0K
Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases14:57

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases

Published on: October 10, 2020

14.8K

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.4K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.1K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.9K
Small GTPases - Ras and Rho01:24

Small GTPases - Ras and Rho

Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
4.8K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.7K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
5.3K