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Deregulated expression of Elastin Microfibril Interfacer 2 (EMILIN2) in gastric cancer affects tumor growth and

Eva Andreuzzi1, Albina Fejza1, Alessandra Capuano1

  • 1Department of Research and Diagnosis, Division of Molecular Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Italy.

Matrix Biology Plus
|February 5, 2021
PubMed

Insights

Gastric cancer research identifies EMILIN2 (Elastin Microfibril Interfacer 2) as a suppressed protein. Its expression impacts tumor growth, apoptosis, and vascular density, offering potential as a biomarker.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Gastric cancer is a prevalent and often fatal malignancy.
  • Targeted therapies for gastric cancer lag behind other solid tumors due to limited actionable mutations.
  • There is a critical need for novel diagnostic/prognostic biomarkers and therapeutic targets in gastric cancer.

Purpose of the Study:

  • To investigate the role of Extracellular Matrix glycoprotein EMILIN2 (Elastin Microfibril Interfacer 2) in gastric cancer.
  • To identify potential diagnostic or prognostic biomarkers for gastric carcinoma.
  • To understand EMILIN2's impact on the gastric cancer microenvironment.

Main Methods:

  • Analysis of EMILIN2 expression in a cohort of gastric cancer patients.
  • Correlation of EMILIN2 levels with vascular density.
  • Assessment of EMILIN2's effects on gastric carcinoma cell proliferation, apoptosis, and cytokine production (e.g., IL-8).

Main Results:

  • EMILIN2 expression was consistently suppressed in gastric cancer tissues.
  • High EMILIN2 levels correlated with abnormal tumor vascular density.
  • EMILIN2 demonstrated a dual role: inhibiting proliferation via apoptosis and stimulating pro-angiogenic/inflammatory cytokines like IL-8.

Conclusions:

  • EMILIN2 acts as a significant onco-regulator in gastric cancer.
  • EMILIN2 influences tumor cell behavior and the tumor microenvironment.
  • EMILIN2 warrants further investigation as a potential therapeutic target and biomarker for gastric cancer.
Keywords:
5-FU, 5-fluorouracilAngiogenesisCAFCA, Centrifugal Assay for Fluorescence-based Cell AdhesionCD31, cluster of differentiation 31 also known as PECAM-1ECM, extracellular matrixEGFR, epidermalgrowth factor receptorEMILIN 2, Elastin Microfibril Interfacer 2Extracellular matrixGC, gastric cancerGastric cancerHER2, human epidermal growth factor receptor 2IGFBP2, insulin growth factor-binding protein 2InflammationPFS, progression free survivalSerpin 1, serine protease inhibitor 1Tumor microenvironmentVEGFA, vascular endothelial growth factor A

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