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Transient hyperphosphatasemia of infancy. Fifteen new cases
R Oggero1, M Mostert, M Spinello
1Department of Paediatrics, Turin University Hospital, Italy.
Acta Paediatrica Scandinavica
|March 1, 1988
Insights
Transient hyperphosphatasemia of infancy (THI) was observed in fifteen children. Clinical signs in these pediatric patients suggested an underlying infectious agent may cause this condition.
Area of Science:
- Pediatric Medicine
- Biochemistry
- Clinical Diagnostics
Background:
- Alkaline phosphatase (ALP) assays are routinely performed in pediatric hospital admissions.
- Transient hyperphosphatasemia of infancy (THI) is a condition characterized by elevated ALP levels.
- Understanding the etiology of THI is crucial for appropriate clinical management.
Observation:
- Routine biochemical screenings identified fifteen pediatric cases of THI.
- These children presented with clinical symptoms indicative of an infectious process.
- The co-occurrence of THI and infection symptoms prompted further investigation.
Findings:
- Elevated alkaline phosphatase levels were detected in fifteen infants during their initial hospitalization.
- Clinical presentations in these infants were suggestive of an infectious etiology.
- A potential link between infectious agents and the development of THI in infants is indicated.
Implications:
- This study highlights a potential association between infections and THI in infants.
- Further research is warranted to confirm the role of infectious agents in THI.
- Identifying infectious triggers could lead to targeted treatments for THI.
Abstract:
Alkaline phosphatase was assayed as part of the routine examinations performed in all children hospitalized for the first time in our ward. Fifteen children had transient hyperphosphatasemia of infancy (THI). Their clinical features suggested the presence of an infectious agent.