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Related Experiment Video

Updated: Nov 18, 2025

A Semantic Priming Event-related Potential ERP Task to Study Lexico-semantic and Visuo-semantic Processing in Autism Spectrum Disorder

A Semantic Priming Event-related Potential ERP Task to Study Lexico-semantic and Visuo-semantic Processing in Autism Spectrum Disorder

Published on: April 12, 2018

Developmental differences in neural connectivity for semantic processing in youths with autism.

Li-Ying Fan^1,2,3, James R Booth⁴, Min Liu^2,3

¹Department of Education, National Taipei University of Education, Taipei, Taiwan.

Journal of Child Psychology and Psychiatry, and Allied Disciplines

|February 5, 2021

Summary

Children with autism spectrum disorder (ASD) show altered brain connectivity during semantic processing. Younger children with ASD exhibit occipital alterations, while adolescents show reduced frontal engagement compared to typically developing peers.

Keywords:

Semantic differential difference fMRI functional connectivity psychophysiological interaction

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Using the Visual World Paradigm to Study Sentence Comprehension in Mandarin-Speaking Children with Autism

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Published on: October 3, 2018

Area of Science:

Neuroscience
Developmental Psychology
Cognitive Science

Background:

Autism spectrum disorder (ASD) is characterized by differences in neural processing.
Youths with ASD show greater occipital activation and reduced frontal activation during semantic tasks.
Limited understanding exists regarding age-dependent neural connectivity in ASD during semantic processing.

Purpose of the Study:

To investigate age-dependent differences in neural connectivity during semantic processing in youths with ASD compared to typically developing (TD) youths.
To explore functional magnetic resonance imaging (fMRI) based psychophysiological interaction (PPI) differences between ASD and TD groups across childhood and adolescence.

Main Methods:

Recruited four groups: ASD children (n=31), TD children (n=33), ASD adolescents (n=30), and TD adolescents (n=34).
Utilized fMRI with PPI during semantic judgment tasks to assess neural connectivity.
Analyzed differences in brain activation and functional connectivity between groups.

Main Results:

Children with ASD showed greater left cuneus activation and weaker connectivity between the left cuneus and left middle temporal gyrus (MTG) compared to TD children.
Adolescents with ASD exhibited less left inferior frontal gyrus (IFG) activation and weaker functional connectivity between the left IFG and left MTG compared to TD adolescents.

Conclusions:

Children with ASD may rely more on visual occipital processes disconnected from temporal semantic areas.
Adolescents with ASD may show less effective top-down control of semantic knowledge due to reduced frontal engagement.
Findings indicate developmental shifts in the neural underpinnings of semantic processing alterations in ASD.