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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
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Age-dependent sex differences in calcium and phosphate homeostasis
W N H Koek1, N Campos-Obando1, B C J van der Eerden1
1Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Endocrine Connections
|February 5, 2021
Summary
Serum calcium and phosphate levels show age-dependent sex differences. Levels are higher in women over 45, with distinct patterns across age groups in both sexes.
Area of Science:
- Biochemistry
- Human Physiology
- Gerontology
Background:
- Observed sex differences in calcium and phosphate metabolism.
- Previous research indicates potential age-related variations.
Purpose of the Study:
- To investigate age-dependent sex differences in serum calcium and phosphate levels.
- To analyze the relationship between age, sex, and these mineral levels.
Main Methods:
- Utilized laboratory data (serum calcium, phosphate, albumin) from three distinct time points (2005, 2010, 2014).
- Employed Analysis of Covariance (ANCOVA) to analyze sex differences, adjusting for age and albumin.
- Examined sex by age interactions and stratified age group differences by sex.
Main Results:
- Significant sex × age interactions were found for serum calcium and phosphate.
- In individuals aged ≥45 years, women exhibited higher calcium and phosphate levels than men.
- Distinct age-related patterns were observed within each sex, with unique variations in women across different age brackets.
Conclusions:
- Age-dependent sex differences in serum calcium and phosphate are confirmed.
- Significant variations exist between different age groups for these minerals.
- The underlying biological mechanisms driving these age- and sex-specific differences require further investigation.
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