Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic alterations of Streptococcus mutans' virulence.

J M Tanzer, M L Freedman

    Advances in Experimental Medicine and Biology
    |January 1, 1978
    PubMed
    Summary

    Investigating bacterial mutants defective in caries-associated traits revealed that agglutination is not crucial for virulence. Identifying surface virulence factors is key for developing targeted immune responses against dental caries.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Addition of Povidone-Iodine to Fluoride Varnish for Dental Caries: A Randomized Clinical Trial.

    JDR clinical and translational research·2020
    Same author

    Lessons from postgenome-wide association studies: functional analysis of cancer predisposition loci.

    Journal of internal medicine·2013
    Same author

    Streptococcus mutans out-competes Streptococcus gordonii in vivo.

    Journal of dental research·2012
    Same author

    Perspectives on PACS: where is caries prevention clinical research going?

    Journal of dental research·2011
    Same author

    Dissociable components of short-term memory and their relation to long-term learning.

    Cognitive neuropsychology·2010
    Same author

    Caries inhibition by and safety of Lactobacillus paracasei DSMZ16671.

    Journal of dental research·2010

    Area of Science:

    • Microbiology
    • Immunology
    • Dental Research

    Background:

    • Dental caries is a complex disease influenced by bacterial virulence factors.
    • Understanding the specific roles of bacterial traits in caries development is crucial for effective prevention and treatment strategies.

    Purpose of the Study:

    • To genetically dissociate bacterial agglutination from adhesion.
    • To determine the contribution of specific bacterial traits, such as glucanohydrolase and agglutination, to virulence and plaque formation.
    • To identify key surface-associated virulence factors for potential vaccine development.

    Main Methods:

    • Utilizing bacterial mutants with defects in caries-associated traits.
    • Analyzing the roles of agglutination, adhesion, glucanohydrolase, and plaque formation in bacterial virulence.
    • Investigating the infectivity and disease-causing potential of plaque formation-defective mutants.

    Main Results:

    • Agglutination was genetically dissociated from adhesion and found to be of limited importance to virulence.
    • Glucanohydrolase was shown to be more important for virulence than for plaque formation.
    • Plaque formation-defective mutants could infect and emerge but did not cause disease, suggesting other factors are critical for pathogenesis.

    Conclusions:

    • Bacterial agglutination is not a primary virulence factor in dental caries.
    • Identifying surface-associated virulence factors is essential for developing targeted immune responses and novel therapeutic strategies against caries.

    Related Experiment Videos