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Endocrine toxicity of cancer immunotherapy: clinical challenges
Bliss Anderson1, Daniel L Morganstein1
1Department of Endocrinology, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.
Abstract:
Immune checkpoint inhibitors are now widely used in the treatment of multiple cancers. The major toxicities of these treatments are termed immune-related adverse events and endocrine dysfunction is common. Thyroid disease, hypopituitarism and a form of diabetes resembling type 1 diabetes are now all well described, with different patterns emerging with different checkpoint inhibitors. We review the presentation and management of the common endocrine immune-related adverse events, and discuss a number of recent advances in the understanding of these important, potentially life threatening toxicities. We also discuss some remaining dilemmas in management.
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