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Updated: Nov 18, 2025

Detection of Protein Aggregation using Fluorescence Correlation Spectroscopy

Detection of Protein Aggregation using Fluorescence Correlation Spectroscopy

Published on: April 25, 2021

Aggregation-Induced Emission Fluorescent Gels: Current Trends and Future Perspectives.

Javad Tavakoli¹, Amin Jamshidi Ghahfarokhi², Youhong Tang³

¹Centre for Health Technologies, School of Biomedical Engineering, Faculty of Engineering and Information Technology, University of Technology Sydney, Ultimo, NSW, 2007, Australia.

Topics in Current Chemistry (Cham)

|February 5, 2021

Summary

This review explores fluorescent gels utilizing aggregation-induced emission fluorophores (AIEgens), highlighting their advantages over traditional fluorophores. It details fabrication methods and biomedical applications for advanced materials.

Keywords:

AIE polymers Aggregation-induced emission Biomedical applications Fluorescent gels Hydrogels

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Area of Science:

Materials Science
Polymer Chemistry
Supramolecular Chemistry

Background:

Fluorescent gels are a new generation of materials with unique properties.
Traditional fluorescent materials face limitations in gel fabrication.
Aggregation-induced emission fluorophores (AIEgens) offer novel solutions.

Purpose of the Study:

To review the development of fluorescent gels using AIEgens.
To compare AIEgen-based gels with traditional fluorescent gels.
To identify future research directions and applications.

Main Methods:

Discusses fabrication strategies: physical mixing, soaking, self-assembly, noncovalent interactions, and chemical reactions.
Explains the preparation of physically and chemically prepared AIE-based gels.
Covers clustering-triggered fluorescence in natural gels.

Main Results:

AIEgens overcome drawbacks of traditional fluorophores in gel fabrication.
Various AIE-based gels (supramolecular, ionic, chemically prepared) have been developed.
AIE-based fluorescent hydrogels show promise in biomedical applications.

Conclusions:

AIEgen-based fluorescent gels represent a significant advancement.
Fabrication methods are diverse, offering flexibility.
Biomedical applications like drug delivery, biosensing, bioimaging, and tissue engineering are key areas for future development.