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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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Long Non-coding RNAs in Parkinson's Disease.

Chengqi Xin1,2, Jing Liu3,4

  • 1Stem Cell Clinical Research Center, National Joint Engineering Laboratory, Regenerative Medicine Center, The First Affiliated Hospital of Dalian Medical University, No. 193, Lianhe Road, Shahekou District, Dalian City, Liaoning Province, 116011, People's Republic of China.

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PubMed
Summary

Long non-coding RNAs (lncRNAs) are implicated in Parkinson's disease (PD) pathogenesis. This review explores lncRNA roles in PD, suggesting their potential as biomarkers for early diagnosis and novel therapeutic targets.

Keywords:
Parkinson’s diseaselong non-coding RNAspathogenesisregulation

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Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • Parkinson's disease (PD) is a prevalent neurodegenerative disorder with complex motor and non-motor symptoms.
  • Its pathogenesis involves α-synuclein, mitochondrial dysfunction, oxidative stress, neuroinflammation, and epigenetic factors.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their regulatory roles in cellular processes relevant to PD.

Purpose of the Study:

  • To review large-scale studies on lncRNA expression profiling in Parkinson's disease.
  • To highlight the impact of lncRNAs on the molecular pathogenesis of PD.
  • To identify potential lncRNA-based biomarkers and therapeutic targets for PD.

Main Methods:

  • Comprehensive literature review of studies investigating lncRNA expression in PD patients and models.
  • Analysis of the functional roles of lncRNAs in key PD pathological pathways.
  • Synthesis of findings to assess the diagnostic and therapeutic potential of lncRNAs in PD.

Main Results:

  • Numerous lncRNAs show altered expression patterns in Parkinson's disease.
  • lncRNAs modulate critical pathways including α-synuclein aggregation, mitochondrial function, and neuroinflammation.
  • Specific lncRNAs are associated with disease progression and severity.

Conclusions:

  • lncRNAs play significant roles in the pathogenesis of Parkinson's disease.
  • lncRNAs represent promising candidates for developing novel biomarkers for early PD diagnosis.
  • Targeting lncRNAs offers a potential strategy for future therapeutic interventions in PD.