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Updated: Nov 18, 2025

Investigating Interactions Between Histone Modifying Enzymes and Transcription Factors in vivo by Fluorescence Resonance Energy Transfer
Published on: October 14, 2022
LOTUS-domain proteins - developmental effectors from a molecular perspective
Jana Kubíková1, Rebecca Reinig1, Harpreet Kaur Salgania1
1Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, D-69120Heidelberg, Germany.
Abstract:
The LOTUS domain (also known as OST-HTH) is a highly conserved protein domain found in a variety of bacteria and eukaryotes. In animals, the LOTUS domain is present in the proteins Oskar, TDRD5/Tejas, TDRD7/TRAP/Tapas, and MARF1/Limkain B1, all of which play essential roles in animal development, in particular during oogenesis and/or spermatogenesis. This review summarizes the diverse biological as well as molecular functions of LOTUS-domain proteins and discusses their roles as helicase effectors, post-transcriptional regulators, and critical cofactors of piRNA-mediated transcript silencing.
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