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Thiol-based redox switches in the major pathogen Staphylococcus aureus.

Nico Linzner1, Vu Van Loi1, Verena Nadin Fritsch1

  • 1Freie Universität Berlin, Institute of Biology-Microbiology, Königin-Luise-Straße 12-16, D-14195Berlin, Germany.

Biological Chemistry
|February 5, 2021
PubMed
Summary

Staphylococcus aureus uses thiol switches and bacillithiol (BSH) to combat host defenses and antibiotics. These systems offer potential as novel drug targets against multi-drug resistant strains.

Keywords:
HOClROSStaphylococcus aureusbacillithiolelectrophilesthiol switches

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