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Left ventricular dysfunction after prolonged strenuous exercise in healthy subjects.

D R Seals1, M A Rogers, J M Hagberg

  • 1Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.

The American Journal of Cardiology
|April 15, 1988
PubMed
Summary
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Prolonged strenuous exercise may temporarily impair left ventricular (LV) function in healthy men, indicated by reduced contractile function. However, brief exercise of similar intensity does not cause these impairments.

Area of Science:

  • Cardiovascular Physiology
  • Exercise Science
  • Sports Medicine

Background:

  • Understanding the cardiac response to prolonged, strenuous exercise is crucial for athlete health.
  • Previous research has not fully elucidated the impact of exhaustive exercise on left ventricular (LV) contractile function.

Purpose of the Study:

  • To investigate whether prolonged and strenuous exercise leads to depressed left ventricular (LV) contractile function in healthy young men.
  • To compare the cardiac response to prolonged exhaustive exercise versus brief, high-intensity exercise.

Main Methods:

  • Twelve healthy men exercised to exhaustion on a treadmill at 69% of maximal oxygen uptake for approximately 170 minutes.
  • Hemodynamic variables, including blood pressure and echocardiographic measurements of LV dimensions and function (fractional shortening, velocity of circumferential fiber shortening), were assessed before and after exercise.

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  • A repeat bout of brief (10-minute) high-intensity exercise was performed for comparison.

    • Main Results:

    • Following prolonged exhaustive exercise, systolic blood pressure decreased, and LV end-diastolic diameter reduced.
    • Both LV fractional shortening and mean velocity of circumferential fiber shortening significantly decreased, indicating impaired LV contractile function, despite lower end-systolic wall stress.
    • Brief, high-intensity exercise, however, led to improved LV contractile function and reduced LV end-diastolic diameter.

    Conclusions:

    • Prolonged strenuous exercise may induce a transient impairment in left ventricular (LV) contractile function in healthy young individuals.
    • The observed LV dysfunction appears to be specific to the prolonged nature of the exercise, as brief intense exercise did not elicit similar effects.
    • These findings highlight the potential for exercise-induced cardiac fatigue following extreme endurance events.