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Related Concept Videos

MicroRNAs01:22

MicroRNAs

3.4K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.4K
MicroRNAs01:22

MicroRNAs

23.2K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.2K

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Updated: Nov 18, 2025

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
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MicroRNA in multiple sclerosis.

Yan Gao1, Dong Han1, Juan Feng1

  • 1Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|February 5, 2021
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) are key regulators in the central nervous system and are implicated in multiple sclerosis (MS) pathogenesis. These molecules show promise as diagnostic biomarkers and therapeutic targets for MS.

Keywords:
AutoimmunityBiomarkersImmune cellsMultiple sclerosismicroRNA

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Area of Science:

  • Neuroimmunology
  • Molecular Biology
  • Genetics

Background:

  • Multiple sclerosis (MS) is a central nervous system autoimmune disease with complex pathogenesis.
  • Immune system dysregulation is a significant factor in MS development.
  • MicroRNAs (miRNAs) are crucial gene regulators involved in cellular processes like proliferation and apoptosis.

Purpose of the Study:

  • To review the role of miRNAs in the pathogenesis of multiple sclerosis.
  • To explore the potential of miRNAs as diagnostic biomarkers for MS.
  • To discuss miRNAs as prospective therapeutic agents for MS.

Main Methods:

  • Literature review of recent studies on miRNAs and MS.
  • Analysis of miRNA involvement in glial and peripheral immune cells in MS.
  • Evaluation of miRNA stability and specificity in body fluids.

Main Results:

  • miRNAs are implicated in the pathogenesis of MS, particularly in glial and immune cells.
  • miRNAs are stable and specific in peripheral body fluids.
  • miRNAs present potential as diagnostic and therapeutic targets for MS.

Conclusions:

  • miRNAs play a significant role in the pathogenesis of multiple sclerosis.
  • The stability and specificity of miRNAs make them promising biomarkers for MS diagnosis.
  • miRNAs offer potential as novel therapeutic strategies for managing MS.