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Recent advances in the regulation of ABCA1 and ABCG1 by lncRNAs

Shun Zhang1, Lu Li1, Jie Wang1

  • 1Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer Institute, Qingdao, Shandong 266071, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|February 5, 2021
PubMed

Insights

Long noncoding RNAs (lncRNAs) regulate cholesterol efflux via ABCA1 and ABCG1, impacting atherosclerosis. This review explores lncRNAs as potential therapeutic targets for this leading cause of death.

Area of Science:

  • Molecular Biology
  • Cardiovascular Research
  • RNA Biology

Background:

  • Coronary heart disease (CHD) and atherosclerosis are major global health concerns.
  • ABCA1 and ABCG1 are key proteins involved in cholesterol efflux, crucial for preventing atherosclerosis.
  • Long noncoding RNAs (lncRNAs) are increasingly recognized for their regulatory roles in cellular processes.

Purpose of the Study:

  • To review the current understanding of lncRNAs in regulating cholesterol efflux through ABCA1 and ABCG1.
  • To highlight novel insights into the functions of specific lncRNAs in atherosclerosis development.
  • To explore the therapeutic potential of lncRNAs targeting ABCA1 and ABCG1 pathways in atherosclerosis.

Main Methods:

  • Comprehensive literature review of studies investigating lncRNAs, ABCA1, ABCG1, cholesterol efflux, and atherosclerosis.
  • Analysis of identified lncRNAs and their specific regulatory mechanisms on ABCA1 and ABCG1.
  • Evaluation of existing in vitro and in vivo data regarding lncRNA functions in atherosclerosis models.

Main Results:

  • Numerous lncRNAs (e.g., MeXis, GAS5, TUG1, MEG3, MALAT1) are identified as regulators of ABCA1-mediated cholesterol efflux.
  • Several lncRNAs (e.g., TUG1, GAS5, RP5-833A20.1) are implicated in regulating ABCG1-mediated cholesterol efflux.
  • Some lncRNAs exhibit dual roles in ABCA1 expression and atherosclerosis, and the in vivo functions of others remain unexplored.

Conclusions:

  • lncRNAs play a significant and complex role in regulating cholesterol efflux via ABCA1 and ABCG1, thereby influencing atherosclerosis.
  • Understanding the specific functions and mechanisms of lncRNAs offers new avenues for therapeutic intervention in atherosclerosis.
  • Further in vivo investigation is warranted to fully elucidate the therapeutic potential of lncRNAs as novel targets for CHD.

Keywords:
ABCA1ABCG1AtherosclerosisCholesterol effluxlncRNAs

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