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Effect of colloidal silicon dioxide and moisture on powder flow properties: Predicting in-process performance using

David Blanco1, Osmo Antikainen1, Heikki Räikkönen1

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Colloidal silicon dioxide (CSD) significantly improves the powder flow of poorly flowing lactose 200M. Optimal CSD concentrations range from 0.10% to 0.50% w/w for enhanced tablet manufacturing performance.

Keywords:
Cohesive powdersColloidal silicon dioxideImage analysisLactoseMoisturePowder flowTablet manufacture

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Powder Technology

Background:

  • Poor powder flow of excipients like lactose 200M hinders efficient tablet manufacturing.
  • Glidants are crucial for improving powder flowability in pharmaceutical formulations.
  • Understanding particle interactions is key to optimizing powder performance.

Purpose of the Study:

  • To investigate the effect of colloidal silicon dioxide (CSD) on the powder flow properties of lactose 200M.
  • To determine the optimal concentration range of CSD for enhancing powder flow.
  • To correlate powder flow improvements with die filling performance in tablet manufacturing.

Main Methods:

  • Preparation of binary mixtures of lactose 200M with varying ratios of CSD.
  • Utilized a modern image-based flow measuring technique to assess powder flow.
  • Investigated subtle variations in flowability due to small changes in CSD concentration (0.025% w/w).
  • Empirically assessed the impact of moisture content on powder flow.

Main Results:

  • A significant improvement in powder flow performance was observed with CSD addition.
  • An efficient range of CSD concentration was identified between 0.10% and 0.50% w/w.
  • The study predicted improved die filling performance based on observed flowability changes.
  • Moisture content was confirmed to significantly influence powder flow properties.

Conclusions:

  • Colloidal silicon dioxide effectively enhances the flow properties of poorly flowing lactose 200M.
  • The optimal CSD concentration for improved powder flow is between 0.10% and 0.50% w/w.
  • This concentration range offers superior performance compared to higher amounts typically used in the pharmaceutical industry.