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Epigenetic reprogramming during prostate cancer progression: A perspective from development.

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Conrad Waddington's epigenetic landscape theory explains cell fate. Its disruption in cancer, particularly prostate cancer (PCa), highlights epigenetic reprogramming's role in development and therapeutic strategies.

Keywords:
Cell fateCell plasticityDifferentiationEpigeneticsProstate cancer

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Area of Science:

  • Developmental Biology
  • Cancer Biology
  • Epigenetics

Background:

  • Conrad Waddington's epigenetic landscape theory models cell fate determination.
  • The epigenetic code regulates gene expression in embryonic development and differentiation.
  • Epigenetic landscape alterations are crucial in cancer progression, with dedifferentiation as a hallmark.

Purpose of the Study:

  • To discuss the role of the epigenetic landscape and its modifiers in cell-fate determination, differentiation, and prostate cancer (PCa) progression.
  • To explore the impact of RNA modifications on epigenetics in cancer.
  • To review the epigenetic code's regulation of androgen signaling and PCa to neuroendocrine PCa transition.

Main Methods:

  • Literature review and theoretical discussion.
  • Analysis of epigenetic reprogramming in development and cancer.
  • Overview of RNA modifications and their role in cancer epigenetics.

Main Results:

  • Epigenetic landscape modifiers are key in cell-fate determination and differentiation.
  • Epigenetic reprogramming is implicated in cancer development and progression.
  • RNA modifications offer new insights into cancer epigenetics.

Conclusions:

  • The epigenetic code is vital for normal prostate gland development and PCa progression.
  • Understanding the cancer cell epigenome has clinical implications for advanced PCa.
  • Recent therapeutic strategies target advanced prostate cancer by modulating the epigenome.