Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcomes of drug-coated balloon combined with stenting vs. stenting alone in the treatment of femoropopliteal artery lesions requiring bailout stenting.

BMC surgery·2026
Same author

Drug-coated balloon combined with stent versus stent alone for femoropopliteal disease: a systematic review and meta-analysis.

BMC cardiovascular disorders·2026
Same author

From Acute Thrombosis to Eccentric Neointima in Arteriovenous Fistula.

Seminars in thrombosis and hemostasis·2026
Same author

Aortotomy-induced acute mural thrombosis progresses to saccular aneurysm formation.

Research and practice in thrombosis and haemostasis·2026
Same author

Association between sarcopenic obesity and kidney stones: evidence from a prospective cohort study on the UK Biobank.

BMC public health·2026
Same author

Characterization of Arteriovenous Thrombus Formation and Propagation in a Mouse Arteriovenous Fistula Model.

Thrombosis and haemostasis·2025

Related Experiment Video

Updated: Nov 18, 2025

Author Spotlight: Enhanced Murine AAA Model Using Elastase to Mimic Human Aneurysms
07:42

Author Spotlight: Enhanced Murine AAA Model Using Elastase to Mimic Human Aneurysms

Published on: July 26, 2024

2.3K

A novel intramural TGF β 1 hydrogel delivery method to decrease murine abdominal aortic aneurysm and rat aortic

Hualong Bai1, Peng Sun2, Shunbo Wei2

  • 1Department of Vascular and Endovascular Surgery, First Affiliated Hospital of Zhengzhou University, Henan, China; Key Vascular Physiology and Applied Research Laboratory of Zhengzhou City, Henan, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|February 5, 2021
PubMed
Summary

Intramural delivery of transforming growth factor beta 1 (TGF β1) hydrogel effectively reduced aneurysm and pseudoaneurysm formation in mouse and rat models. This novel therapeutic approach shows promise for clinical applications in preventing vascular diseases.

Keywords:
AneurysmHydrogelIntramural deliveryPseudoaneurysmTGF β 1

More Related Videos

A New Murine Model of Endovascular Aortic Aneurysm Repair
08:51

A New Murine Model of Endovascular Aortic Aneurysm Repair

Published on: July 7, 2013

14.6K
Mouse Abdominal Aortic Aneurysm Model Induced by Perivascular Application of Elastase
04:49

Mouse Abdominal Aortic Aneurysm Model Induced by Perivascular Application of Elastase

Published on: February 11, 2022

5.8K

Related Experiment Videos

Last Updated: Nov 18, 2025

Author Spotlight: Enhanced Murine AAA Model Using Elastase to Mimic Human Aneurysms
07:42

Author Spotlight: Enhanced Murine AAA Model Using Elastase to Mimic Human Aneurysms

Published on: July 26, 2024

2.3K
A New Murine Model of Endovascular Aortic Aneurysm Repair
08:51

A New Murine Model of Endovascular Aortic Aneurysm Repair

Published on: July 7, 2013

14.6K
Mouse Abdominal Aortic Aneurysm Model Induced by Perivascular Application of Elastase
04:49

Mouse Abdominal Aortic Aneurysm Model Induced by Perivascular Application of Elastase

Published on: February 11, 2022

5.8K

Area of Science:

  • Biomedical Engineering
  • Vascular Biology
  • Regenerative Medicine

Background:

  • Aneurysms and pseudoaneurysms involve vessel wall dilation and contained blood leakage, respectively.
  • Current protocols for preventing aneurysm formation and progression are lacking.
  • Transforming growth factor beta 1 (TGF β1) plays a role in vascular remodeling.

Purpose of the Study:

  • To investigate the efficacy of intramural delivery of TGF β1 hydrogel in preventing aneurysm and pseudoaneurysm formation and progression.
  • To evaluate TGF β1 hydrogel as a potential therapeutic strategy for vascular diseases.

Main Methods:

  • Fabrication of TGF β1 hydrogels using sodium alginate (SA), hyaluronic acid (HA), and calcium carbonate (CaCO3).
  • Establishment of mouse CaCl2-induced adventitial incubation model and rat decellularized saphenous vein patch angioplasty pseudoaneurysm model.
  • Intramural delivery of TGF β1 hydrogel in both animal models and pig aortas, followed by histological and immunohistochemical analysis.

Main Results:

  • TGF β1 hydrogel delivery in mice resulted in thicker vessel walls and reduced elastin breaks in aneurysm models.
  • Intramural TGF β1 hydrogel administration decreased pseudoaneurysm formation in rats and increased expression of p-smad2 and TAK1.
  • Hydrogel delivery was successfully achieved in pig aortas, demonstrating feasibility.

Conclusions:

  • Intramural delivery of TGF β1 hydrogel is an effective method to decrease aneurysm and pseudoaneurysm formation and progression.
  • This technique represents a promising drug delivery strategy for clinical treatment of vascular diseases.
  • Further research may validate this approach for therapeutic applications.