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Nephrotic syndrome associated with Kimura's disease.
T V Whelan1, J F Maher, P Kragel
1Department of Medicine, Naval Hospital, Bethesda, MD 20814.
Summary
Kimura disease, a condition typically affecting the skin, can also cause kidney problems like nephrotic syndrome. This case highlights successful treatment of associated renal impairment with prednisone.
Area of Science:
- Nephrology
- Dermatology
- Pathology
Background:
- Kimura disease is characterized by skin and soft tissue lesions, often involving the head and neck.
- A significant association exists between Kimura disease and renal pathology, though its presentation varies.
- This report details a unique case of Kimura disease manifesting in the Western hemisphere.
Observation:
- The patient presented with nephrotic syndrome, a severe kidney disorder.
- Renal biopsy revealed mesangial proliferative glomerulonephritis, indicating significant kidney impairment.
- The patient's initial presentation occurred outside of endemic regions for Kimura disease.
Findings:
- The patient's nephrotic syndrome demonstrated a positive response to standard prednisone therapy.
- This case illustrates the potential for Kimura disease to present with significant renal manifestations.
- Successful management of renal impairment was achieved with corticosteroids.
Implications:
- This case broadens the understanding of Kimura disease's geographical and clinical spectrum.
- It underscores the importance of considering Kimura disease in patients with unexplained nephrotic syndrome.
- The findings support the efficacy of corticosteroid treatment for Kimura disease-associated glomerulonephritis.