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Bifunctional polymer brush-grafted coronary stent for anticoagulation and endothelialization
Tianyu Zhu1, Wentao Gao2, Dan Fang1
1National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.
Summary
This study developed a novel bifunctional polymer brush-coated coronary stent. The stent combines anticoagulant properties with nitric oxide (NO) release to significantly improve endothelialization and reduce thrombosis risks.
Area of Science:
- Biomaterials Science
- Cardiovascular Engineering
- Polymer Chemistry
Background:
- Cardiovascular stent implantation can lead to complications like delayed endothelialization, thrombosis, and restenosis.
- Current stent coatings often lack combined anticoagulant and endothelial promotion functions.
Purpose of the Study:
- To develop a bifunctional polymer brush-grafted coronary stent with enhanced anticoagulant and endothelial functions.
- To address clinical challenges of delayed endothelialization, late thrombosis, and restenosis post-stent implantation.
Main Methods:
- Surface-induced grafting of a zwitterionic block copolymer brush (SBMA-GMA) onto a bare metal coronary stent via atom transfer radical polymerization.
- Attachment of diethylenetriamine NONOate (DETA NONOate) as a nitric oxide (NO) donor to the polyglycidyl methacrylate (PGMA) brush.
- Characterization of chemical modification, NO release, anticoagulant properties, cytotoxicity, endothelial cell proliferation, and in vivo animal experiments.
Main Results:
- Successful synthesis of a bifunctional polymer brush coating on coronary stents.
- Demonstrated effective nitric oxide (NO) release from the modified stent.
- Exhibited excellent anticoagulant properties and no cytotoxicity.
- Showcased significant endothelial cell (EC) proliferation and endothelialization effect in tests.
- Animal experiments confirmed the stent's efficacy in promoting healing and reducing adverse events.
Conclusions:
- The developed zwitterion-modified and NO-releasing bifunctional coating significantly improves stent performance.
- This approach effectively combines the anticoagulant benefits of zwitterions with the endothelialization promotion of NO.
- The novel stent coating shows great potential for mitigating restenosis and late stent thrombosis, improving cardiovascular intervention outcomes.
